IMPORTANCE OF SOLUBILITY AND SOLUBILITY ENHANCEMENT TECHNIQUES
نویسندگان
چکیده
منابع مشابه
Drug Solubility: Importance and Enhancement Techniques
Solubility, the phenomenon of dissolution of solute in solvent to give a homogenous system, is one of the important parameters to achieve desired concentration of drug in systemic circulation for desired (anticipated) pharmacological response. Low aqueous solubility is the major problem encountered with formulation development of new chemical entities as well as for the generic development. Mor...
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Solubility, the phenomenon of dissolution of solute in solvent to give a homogenous system, is one of the important parameters to achieve desired concentration of drug in systemic circulation for desired (anticipated) pharmacological response. The major problem encountered with formulation development of new chemical entities as well as for the generic development is low aqueous solubility. It ...
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Clopidogrel, an inhibitor of platelet aggregation, selectively inhibits the binding of adenosine diphosphate (ADP) to its platelet receptor and the subsequent ADP-mediated activation of the glycoprotein GPIIb/IIIa complex, thereby inhibiting platelet aggregation. Oral bioavailability of clopidogrel is very low (less than 50%), due to its poor water solubility. The aim of this investigation was ...
متن کاملDevelopment of Microemulsion for Solubility Enhancement of Clopidogrel
Clopidogrel, an inhibitor of platelet aggregation, selectively inhibits the binding of adenosine diphosphate (ADP) to its platelet receptor and the subsequent ADP-mediated activation of the glycoprotein GPIIb/IIIa complex, thereby inhibiting platelet aggregation. Oral bioavailability of clopidogrel is very low (less than 50%), due to its poor water solubility. The aim of this investigation was ...
متن کاملSolubility enhancement in supercritical solvents
The enhancement of solubility of a solid in a supercritical solvent is interpreted with emphasis placed on binary mixtures of the second class. The selection of supercritical solvent ; the choice of temperature and pressure for supercritical fluid extractions; the characteristics of solubility curves between and in the vicinities of the upper critical and the lower critical end points; the effe...
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ژورنال
عنوان ژورنال: Journal of Medical Pharmaceutical And Allied Sciences
سال: 2019
ISSN: 2320-7418
DOI: 10.22270/jmpas.v8i6.878